Emmanuel Mané-Katz was born in 1894 in Kremenchug, Ukraine.
Mané-Katz came from an orthodox Jewish family, his father was sexton of a synagogue, and he was originally intended to become a Rabbi.
After studying at the School of Fine Arts in Kiev, Mané-Katz visited Paris for the first time in 1913 and enrolled in Fernand Cormon's class at the Ecole des Beaux-Arts, where his fellow students included Chaim Soutine.
Mané-Katz was influenced by Rembrandt, by the Fauves (especially Derain) and, briefly, by Cubism. He returned to Ukraine after the outbreak of World War I. There he was appointed professor at the academy in Khar'kov in 1917.
After the Revolution Mané-Katz left again for Paris in 1921, this time with the intention of taking as his principal theme life in the ghettos of Eastern Europe, the rabbis and Talmudic students, the fiddlers and drummers, comedians and beggars. He also painted a number of landscapes and flower studies. His style became expressionist and baroque, with loose brushwork and rhythmical forms.
Mané-Katz obtained French citizenship in 1927 but after the fall of France took refuge from 1940 to 1945 in New York, where he also began to make a few sculptures. After the war his paintings became much bolder in their colors and patterning. He made a number of visits to Israel and left the works in his possession to the town of Haifa, where they formed the basis of a museum devoted to his work. Mané-Katz died in 1962.